Options in Settings affect how Comic Life behaves, and they apply to all of your Comic Life documents.
For New Documents: You can choose whether the template chooser or a blank document should be shown when Comic Life launches.
Save as package: Allows you to save as a standard Mac OS X document package. Note this is not portable to Windows or easy to upload to Dropbox.
Show Script Editor on right: by default the script editor will be shown above the comic layout editor. For users with widescreen displays locating the script editor on the right by default might be preferable.
Editing:
Normally, balloons and lettering are not clipped by panels, because many photos do not have room for them. If you prefer these to be clipped by default (clipping provides a crisper look to the comic) enable the "Clip new non-image elements" checkbox.
Usually Comic Life plays entertaining sounds while you're editing the comic. If you'd like to turn these off, uncheck "Play sounds".
Software Update:
Normally, Comic Life checks for updates every time it is launched. This allows you to keep up with new releases as they become available. If you prefer not to get these automatic notifications, uncheck this preference. If you'd like to check manually, choose Check for Updates... from the Comic Life menu.
Default Zoom:
Set your preferred default zoom level.
Ruler Units:
By default Comic Life uses Points (in countries that normal use traditional units) or Centimeters (for metric countries), but you can select different units if you prefer.
For centered ruler origins check the "Place origin at center of ruler" box.
By default the comic layout pages are centered in the view. Uncheck "Center the comic page in view" to left-align the comic pages.
Alignment Guides: lets you pick a preferred color for the alignment guides
Spacing Guides: lets you pick a preferred color for the spacing guides